hisA1 protein (Ruegeria sp. TM1040) - STRING interaction network

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Score

hisA1

Histidine biosynthesis. (247 aa)

Predicted Functional Partners:

hisI

0.996

hisH

0.995

hisF

0.987

hisB

0.965

hisE

0.936

hisA2

0.912

ABF63238.1

0.839

hisC

0.780

ABF64713.1

0.764

ABF63237.1

0.760

Your Current Organism:

Ruegeria sp. TM1040

NCBI taxonomy Id: 292414
Other names: R. sp. TM1040, Silicibacter sp. TM1040

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABF63237.1	ABF63238.1	TM1040_0504	TM1040_0505	ATP phosphoribosyltransferase regulatory subunit.	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	0.999
ABF63237.1	ABF64713.1	TM1040_0504	TM1040_1981	ATP phosphoribosyltransferase regulatory subunit.	Aminotransferase.	0.722
ABF63237.1	hisA1	TM1040_0504	TM1040_1053	ATP phosphoribosyltransferase regulatory subunit.	Histidine biosynthesis.	0.760
ABF63237.1	hisA2	TM1040_0504	TM1040_2039	ATP phosphoribosyltransferase regulatory subunit.	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.	0.760
ABF63237.1	hisB	TM1040_0504	TM1040_2033	ATP phosphoribosyltransferase regulatory subunit.	Imidazoleglycerol-phosphate dehydratase.	0.932
ABF63237.1	hisC	TM1040_0504	TM1040_2101	ATP phosphoribosyltransferase regulatory subunit.	Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.675
ABF63237.1	hisE	TM1040_0504	TM1040_2042	ATP phosphoribosyltransferase regulatory subunit.	phosphoribosyl-ATP pyrophosphatase.	0.987
ABF63237.1	hisF	TM1040_0504	TM1040_2041	ATP phosphoribosyltransferase regulatory subunit.	Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.929
ABF63237.1	hisH	TM1040_0504	TM1040_2034	ATP phosphoribosyltransferase regulatory subunit.	Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.906
ABF63237.1	hisI	TM1040_0504	TM1040_1394	ATP phosphoribosyltransferase regulatory subunit.	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.906
ABF63238.1	ABF63237.1	TM1040_0505	TM1040_0504	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	ATP phosphoribosyltransferase regulatory subunit.	0.999
ABF63238.1	ABF64713.1	TM1040_0505	TM1040_1981	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Aminotransferase.	0.815
ABF63238.1	hisA1	TM1040_0505	TM1040_1053	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Histidine biosynthesis.	0.839
ABF63238.1	hisA2	TM1040_0505	TM1040_2039	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.	0.833
ABF63238.1	hisB	TM1040_0505	TM1040_2033	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Imidazoleglycerol-phosphate dehydratase.	0.958
ABF63238.1	hisC	TM1040_0505	TM1040_2101	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.806
ABF63238.1	hisE	TM1040_0505	TM1040_2042	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	phosphoribosyl-ATP pyrophosphatase.	0.994
ABF63238.1	hisF	TM1040_0505	TM1040_2041	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.961
ABF63238.1	hisH	TM1040_0505	TM1040_2034	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.965
ABF63238.1	hisI	TM1040_0505	TM1040_1394	ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.	0.962