STRINGSTRING
fhs fhs folD folD purH purH purN purN glyA glyA ABF63919.1 ABF63919.1 ABF64201.1 ABF64201.1 ABF63906.1 ABF63906.1 ABF65125.1 ABF65125.1 ABF64461.1 ABF64461.1 gcvP gcvP
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
fhsFormate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)    
Predicted Functional Partners:
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.998
purH
IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.987
purN
Phosphoribosylglycinamide formyltransferase.
  
 0.972
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.965
ABF63919.1
Pterin-binding enzyme domain protein.
    
 0.940
ABF64201.1
Homocysteine S-methyltransferase.
  
 
 0.923
ABF63906.1
Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family.
  
 0.922
ABF65125.1
Glycine cleavage system T protein.
  
 0.922
ABF64461.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.920
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.838
Your Current Organism:
Ruegeria sp. TM1040
NCBI taxonomy Id: 292414
Other names: R. sp. TM1040, Silicibacter sp. TM1040
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