node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABF63906.1 | ABF63919.1 | TM1040_1173 | TM1040_1186 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Pterin-binding enzyme domain protein. | 0.907 |
ABF63906.1 | ABF64201.1 | TM1040_1173 | TM1040_1468 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Homocysteine S-methyltransferase. | 0.916 |
ABF63906.1 | ABF64461.1 | TM1040_1173 | TM1040_1728 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.905 |
ABF63906.1 | ABF65125.1 | TM1040_1173 | TM1040_2393 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Glycine cleavage system T protein. | 0.924 |
ABF63906.1 | fhs | TM1040_1173 | TM1040_2358 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.922 |
ABF63906.1 | folD | TM1040_1173 | TM1040_2356 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
ABF63906.1 | gcvP | TM1040_1173 | TM1040_2391 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.997 |
ABF63906.1 | glyA | TM1040_1173 | TM1040_1579 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
ABF63906.1 | purH | TM1040_1173 | TM1040_0091 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.920 |
ABF63906.1 | purN | TM1040_1173 | TM1040_1475 | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase. | 0.914 |
ABF63919.1 | ABF63906.1 | TM1040_1186 | TM1040_1173 | Pterin-binding enzyme domain protein. | Glycine cleavage T protein (aminomethyl transferase); Belongs to the GcvT family. | 0.907 |
ABF63919.1 | ABF64201.1 | TM1040_1186 | TM1040_1468 | Pterin-binding enzyme domain protein. | Homocysteine S-methyltransferase. | 0.999 |
ABF63919.1 | ABF64461.1 | TM1040_1186 | TM1040_1728 | Pterin-binding enzyme domain protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
ABF63919.1 | ABF65125.1 | TM1040_1186 | TM1040_2393 | Pterin-binding enzyme domain protein. | Glycine cleavage system T protein. | 0.907 |
ABF63919.1 | fhs | TM1040_1186 | TM1040_2358 | Pterin-binding enzyme domain protein. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.940 |
ABF63919.1 | folD | TM1040_1186 | TM1040_2356 | Pterin-binding enzyme domain protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.432 |
ABF63919.1 | gcvP | TM1040_1186 | TM1040_2391 | Pterin-binding enzyme domain protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.491 |
ABF63919.1 | glyA | TM1040_1186 | TM1040_1579 | Pterin-binding enzyme domain protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
ABF63919.1 | purH | TM1040_1186 | TM1040_0091 | Pterin-binding enzyme domain protein. | IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.900 |
ABF63919.1 | purN | TM1040_1186 | TM1040_1475 | Pterin-binding enzyme domain protein. | Phosphoribosylglycinamide formyltransferase. | 0.900 |