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glnD glnD Tbd_0808 Tbd_0808 Tbd_0240 Tbd_0240 map map glnE glnE Tbd_2503 Tbd_2503 bamA bamA Tbd_2501 Tbd_2501 Tbd_2767 Tbd_2767 Tbd_2652 Tbd_2652 rpsB rpsB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glnDMetal dependent phosphohydrolase, HD region; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (850 aa)    
Predicted Functional Partners:
Tbd_0808
Nitrogen regulatory protein P-II (GlnB, GlnK); Belongs to the P(II) protein family.
 
 
 0.981
Tbd_0240
Nitrogen regulatory protein P-II (GlnB, GlnK); Belongs to the P(II) protein family.
 
 
 
 0.829
map
Peptidase M24A, methionine aminopeptidase, subfamily 1; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.821
glnE
Putative glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the sign [...]
 
   
 0.790
Tbd_2503
Glutamine synthetase type I.
 
   
 0.619
bamA
Surface antigen (D15); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.615
Tbd_2501
PAS/PAC Sensor Signal Transduction Histidine Kinase.
  
 
 
 0.578
Tbd_2767
Glutamate synthase large subunit.
     
 0.568
Tbd_2652
Nitrogen regulatory protein P-II (GlnB, GlnK).
   
 
 0.543
rpsB
Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
     
 0.525
Your Current Organism:
Thiobacillus denitrificans ATCC 25259
NCBI taxonomy Id: 292415
Other names: T. denitrificans ATCC 25259, Thiobacillus denitrificans str. ATCC 25259, Thiobacillus denitrificans strain ATCC 25259
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