STRINGSTRING
hisA hisA hisI hisI hisF hisF hisH hisH hisB hisB hisG hisG hisD hisD hisC hisC guaA guaA BF2490 BF2490 BF4397 BF4397
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Similar to sp:HIS4_BACTN [Bacteroides thetaiotaomicron VPI-5482], percent identity 79 in 239 aa, BLASTP E(): e-109. (239 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-ATP pyrophosphohydrolase; Similar to gp:AE016931_168 [Bacteroides thetaiotaomicron VPI-5482], percent identity 89 in 203 aa, BLASTP E(): e-104; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.999
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisB
Histidine biosynthesis bifunctional protein HisB; Similar to gp:AE016926_203 [Bacteroides thetaiotaomicron VPI-5482], percent identity 93 in 374 aa, BLASTP E(): 0.0; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
  
 0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.983
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.978
hisC
Histidinol-phosphate aminotransferase; Similar to gp:AE016926_202 [Bacteroides thetaiotaomicron VPI-5482], percent identity 83 in 345 aa, BLASTP E(): e-168; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.887
guaA
Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.777
BF2490
Aminotransferase involved in cobalamin biosynthesis CobC; Similar to gpu:AE017176_25 [Porphyromonas gingivalis W83], percent identity 55 in 331 aa, BLASTP E(): e-102.
 
  
 0.755
BF4397
Hemolysin erythrocyte lysis protein; Similar to gp:AF052516_3 [Prevotella intermedia], percent identity 50 in 601 aa, BLASTP E(): e-180.
  
  
 0.720
Your Current Organism:
Bacteroides fragilis
NCBI taxonomy Id: 295405
Other names: B. fragilis YCH46, Bacteroides fragilis YCH46, Bacteroides fragilis str. YCH46, Bacteroides fragilis strain YCH46
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