node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABS23211.1 | ABS23220.1 | Bcer98_2984 | Bcer98_2993 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: btl:BALH_3859 possible 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.467 |
ABS23211.1 | fhs | Bcer98_2984 | Bcer98_1593 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
ABS23211.1 | fmt | Bcer98_2984 | Bcer98_2518 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.946 |
ABS23211.1 | folD | Bcer98_2984 | Bcer98_2874 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
ABS23211.1 | gcvT | Bcer98_2984 | Bcer98_2915 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.956 |
ABS23211.1 | glyA | Bcer98_2984 | Bcer98_3835 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
ABS23211.1 | purH | Bcer98_2984 | Bcer98_0277 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bat:BAS0285 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.946 |
ABS23211.1 | purN | Bcer98_2984 | Bcer98_0276 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.945 |
ABS23211.1 | thyA | Bcer98_2984 | Bcer98_1639 | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.940 |
ABS23220.1 | ABS23211.1 | Bcer98_2993 | Bcer98_2984 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: btl:BALH_3859 possible 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | 0.467 |
ABS23220.1 | folD | Bcer98_2993 | Bcer98_2874 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: btl:BALH_3859 possible 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.933 |
ABS23220.1 | glyA | Bcer98_2993 | Bcer98_3835 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: btl:BALH_3859 possible 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.476 |
ABS23220.1 | purN | Bcer98_2993 | Bcer98_0276 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: btl:BALH_3859 possible 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
fhs | ABS23211.1 | Bcer98_1593 | Bcer98_2984 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | 0.952 |
fhs | folD | Bcer98_1593 | Bcer98_2874 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | gcvT | Bcer98_1593 | Bcer98_2915 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.950 |
fhs | glyA | Bcer98_1593 | Bcer98_3835 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
fhs | purH | Bcer98_1593 | Bcer98_0277 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bat:BAS0285 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.982 |
fhs | purN | Bcer98_1593 | Bcer98_0276 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: baa:BA_2602 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
fmt | ABS23211.1 | Bcer98_2518 | Bcer98_2984 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: btl:BALH_3851 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase. | 0.946 |