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apt apt guaA guaA gmk gmk purH purH purB purB adk adk surE surE CAK29404.1 CAK29404.1 hisF hisF hisH hisH CAK27743.1 CAK27743.1
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 0.998
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.964
purH
Bifunctional purine biosynthesis protein (AICAR transformylase/IMP cyclohydrolase).
  
 0.960
purB
Adenylosuccinate lyase; Nucleotide transport and metabolism; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.959
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 
 0.947
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.912
CAK29404.1
Nucleoside deaminase; Nucleotide transport and metabolism.
  
 
  0.903
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
   
 
 0.823
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 
  0.800
CAK27743.1
Putative translation initiation inhibitor; Translation, ribosomal structure and biogenesis.
 
  
 0.782
Your Current Organism:
Synechococcus sp. RCC307
NCBI taxonomy Id: 316278
Other names: S. sp. RCC307, Synechococcus sp. MINSyn016-15m-01 substr. AC6A1
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