STRINGSTRING
hisA hisA hisI hisI hisF hisF hisH hisH hisB hisB hisD hisD hisG hisG hisC hisC guaA guaA Sden_1032 Sden_1032 Sden_0098 Sden_0098
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (250 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.999
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisB
Histidinol-phosphate phosphatase / imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
  
 0.998
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.991
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.991
hisC
Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.990
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.900
Sden_1032
Phosphoserine phosphatase.
  
  
 0.867
Sden_0098
PfkB.
  
    0.830
Your Current Organism:
Shewanella denitrificans
NCBI taxonomy Id: 318161
Other names: S. denitrificans OS217, Shewanella denitrificans OS217, Shewanella denitrificans str. OS217, Shewanella denitrificans strain OS217
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