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trmFO trmFO Pden_4079 Pden_4079 Pden_3995 Pden_3995 topA topA Pden_2378 Pden_2378 rplY rplY argS argS Pden_2720 Pden_2720 trmD trmD tdk tdk pyrG pyrG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
trmFOGid protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (446 aa)    
Predicted Functional Partners:
Pden_4079
PFAM: glutamyl-tRNA synthetase, class Ic; KEGG: rsp:RSP_2628 glutamyl-/glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
     0.884
Pden_3995
Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
  
    0.683
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
    0.613
Pden_2378
PFAM: putative RNA methylase; KEGG: sit:TM1040_2415 putative RNA methylase.
   
    0.538
rplY
LSU ribosomal protein L25P; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
       0.527
argS
KEGG: rsp:RSP_2943 arginyl-tRNA synthetase, class I; TIGRFAM: arginyl-tRNA synthetase.
  
    0.512
Pden_2720
PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; methyltransferase small; KEGG: sil:SPO3376 ribosomal RNA small subunit methyltransferase B, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
    0.504
trmD
tRNA (Guanine37-N(1)-) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
  
  
 0.504
tdk
PFAM: thymidine kinase; KEGG: rde:RD1_3494 thymidine kinase.
  
  
 0.481
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
    0.458
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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