STRINGSTRING
hisA hisA hisI hisI hisH hisH hisF hisF hisD hisD hisB hisB hisG hisG hisC hisC hisZ hisZ guaA guaA Dgeo_2160 Dgeo_2160
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
hisATIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase: (1e-115); PFAM: histidine biosynthesis: (1.4e-96); KEGG: dra:DR2495 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, ev=1e-104, 82% identity. (243 aa)    
Predicted Functional Partners:
hisI
PFAM: phosphoribosyl-AMP cyclohydrolase: (2.3e-45) phosphoribosyl-ATP pyrophosphohydrolase: (4.2e-36); KEGG: dra:DR0733 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase, ev=1e-102, 86% identity; In the N-terminal section; belongs to the PRA-CH family.
 
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.995
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.995
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.991
hisB
PFAM: imidazoleglycerol-phosphate dehydratase: (1.1e-62); KEGG: dra:DR0424 imidazoleglycerol-phosphate dehydratase, ev=1e-89, 84% identity.
 
  
 0.987
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.982
hisC
PFAM: aminotransferase, class I and II: (1.2e-48); KEGG: dra:DR2461 histidinol-phosphate aminotransferase, ev=1e-137, 67% identity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.976
hisZ
ATP phosphoribosyltransferase, Histidyl-tRNA synthetase-like protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
  
  
 0.900
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.796
Dgeo_2160
PFAM: glycosyl transferase, group 1: (7.8e-30); KEGG: dra:DR0444 lipopolysaccharide biosynthesis protein, putative, ev=1e-160, 72% identity.
  
    0.776
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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