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dltC dltC dltA dltA LSEI_0795 LSEI_0795 LSEI_0797 LSEI_0797 LSEI_2116 LSEI_2116 LSEI_2114 LSEI_2114 rplU rplU LSEI_2451 LSEI_2451 LSEI_2107 LSEI_2107 rpmF rpmF rplM rplM
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dltCD-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (81 aa)    
Predicted Functional Partners:
dltA
D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...]
 
 0.999
LSEI_0795
D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane.
 
 
 0.999
LSEI_0797
D-alanyl transfer protein.
 
  
 0.999
LSEI_2116
[Acyl-carrier-protein] S-malonyltransferase.
  
 0.957
LSEI_2114
3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 0.939
rplU
LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
 
 0.937
LSEI_2451
Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.
  
 0.921
LSEI_2107
Predicted nucleoside-diphosphate-sugar epimerase.
   
 0.920
rpmF
LSU ribosomal protein L32P; Belongs to the bacterial ribosomal protein bL32 family.
  
 
 0.916
rplM
LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
   0.916
Your Current Organism:
Lactobacillus paracasei
NCBI taxonomy Id: 321967
Other names: L. paracasei ATCC 334, Lactobacillus casei ATCC 334, Lactobacillus casei str. ATCC 334, Lactobacillus casei strain ATCC 334, Lactobacillus paracasei ATCC 334
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