node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRAAL0817 | glpK | FRAAL0817 | FRAAL4566 | Putative ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.926 |
FRAAL0817 | prcA | FRAAL0817 | FRAAL2874 | Putative ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.803 |
FRAAL0817 | prcB | FRAAL0817 | FRAAL2873 | Putative ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 20S proteasome beta-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.803 |
FRAAL0817 | pup | FRAAL0817 | FRAAL2871 | Putative ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.683 |
FRAAL2870 | FRAAL6599 | FRAAL2870 | FRAAL6599 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.671 |
FRAAL2870 | arc | FRAAL2870 | FRAAL2869 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | H+-transporting ATP synthase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.927 |
FRAAL2870 | panB | FRAAL2870 | FRAAL5171 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.418 |
FRAAL2870 | prcA | FRAAL2870 | FRAAL2874 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.912 |
FRAAL2870 | prcB | FRAAL2870 | FRAAL2873 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 20S proteasome beta-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.904 |
FRAAL2870 | pup | FRAAL2870 | FRAAL2871 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.937 |
FRAAL2872 | prcA | FRAAL2872 | FRAAL2874 | Hypothetical protein; No homology to any previously reported sequences. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.773 |
FRAAL2872 | prcB | FRAAL2872 | FRAAL2873 | Hypothetical protein; No homology to any previously reported sequences. | 20S proteasome beta-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.773 |
FRAAL6599 | FRAAL2870 | FRAAL6599 | FRAAL2870 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.671 |
FRAAL6599 | arc | FRAAL6599 | FRAAL2869 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | H+-transporting ATP synthase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.823 |
FRAAL6599 | pafA | FRAAL6599 | FRAAL2878 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.732 |
FRAAL6599 | prcA | FRAAL6599 | FRAAL2874 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 20S proteasome alpha-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.990 |
FRAAL6599 | prcB | FRAAL6599 | FRAAL2873 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 20S proteasome beta-subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.921 |
FRAAL6599 | pup | FRAAL6599 | FRAAL2871 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.738 |
arc | FRAAL2870 | FRAAL2869 | FRAAL2870 | H+-transporting ATP synthase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.927 |
arc | FRAAL6599 | FRAAL2869 | FRAAL6599 | H+-transporting ATP synthase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.823 |