node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Swol_1442 | Swol_2353 | Swol_1442 | Swol_2353 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.914 |
Swol_1442 | fhs | Swol_1442 | Swol_1409 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.966 |
Swol_1442 | folD1 | Swol_1442 | Swol_0566 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.545 |
Swol_1442 | folD2 | Swol_1442 | Swol_1474 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.545 |
Swol_1442 | gcvT | Swol_1442 | Swol_1983 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.969 |
Swol_1442 | glyA | Swol_1442 | Swol_2392 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Ribose-5-phosphate isomerase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
Swol_1442 | guaA | Swol_1442 | Swol_1784 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.660 |
Swol_1442 | purH | Swol_1442 | Swol_1775 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | KEGG: mta:Moth_2044 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.912 |
Swol_1442 | purN | Swol_1442 | Swol_1776 | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
Swol_2353 | Swol_1442 | Swol_2353 | Swol_1442 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | 0.914 |
Swol_2353 | fhs | Swol_2353 | Swol_1409 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.903 |
Swol_2353 | folD1 | Swol_2353 | Swol_0566 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.913 |
Swol_2353 | folD2 | Swol_2353 | Swol_1474 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.913 |
Swol_2353 | gcvT | Swol_2353 | Swol_1983 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.907 |
Swol_2353 | glyA | Swol_2353 | Swol_2392 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Ribose-5-phosphate isomerase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
Swol_2353 | purH | Swol_2353 | Swol_1775 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | KEGG: mta:Moth_2044 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.910 |
Swol_2353 | purN | Swol_2353 | Swol_1776 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
fhs | Swol_1442 | Swol_1409 | Swol_1442 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase (B12-dependent); KEGG: pca:Pcar_2722 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation. | 0.966 |
fhs | Swol_2353 | Swol_1409 | Swol_2353 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.903 |
fhs | folD1 | Swol_1409 | Swol_0566 | KEGG: chy:CHY_2385 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |