node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfum_0400 | Sfum_3083 | Sfum_0400 | Sfum_3083 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | 0.912 |
Sfum_0400 | Sfum_3130 | Sfum_0400 | Sfum_3130 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | PFAM: methylenetetrahydrofolate reductase; KEGG: chy:CHY_1233 methylenetetrahydrofolate reductase family protein; Belongs to the methylenetetrahydrofolate reductase family. | 0.913 |
Sfum_0400 | fhs | Sfum_0400 | Sfum_2687 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dps:DP2227 probable formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.904 |
Sfum_0400 | fmt | Sfum_0400 | Sfum_0148 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.925 |
Sfum_0400 | folD | Sfum_0400 | Sfum_2686 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.922 |
Sfum_0400 | glyA | Sfum_0400 | Sfum_1377 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
Sfum_0400 | purN | Sfum_0400 | Sfum_0434 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
Sfum_0400 | purN-2 | Sfum_0400 | Sfum_1185 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
Sfum_0477 | fhs | Sfum_0477 | Sfum_2687 | 5-formyltetrahydrofolate cyclo-ligase-like; KEGG: mmu:234814 methenyltetrahydrofolate synthetase domain containing. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dps:DP2227 probable formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.937 |
Sfum_0477 | folD | Sfum_0477 | Sfum_2686 | 5-formyltetrahydrofolate cyclo-ligase-like; KEGG: mmu:234814 methenyltetrahydrofolate synthetase domain containing. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
Sfum_0477 | glyA | Sfum_0477 | Sfum_1377 | 5-formyltetrahydrofolate cyclo-ligase-like; KEGG: mmu:234814 methenyltetrahydrofolate synthetase domain containing. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.416 |
Sfum_0477 | purN | Sfum_0477 | Sfum_0434 | 5-formyltetrahydrofolate cyclo-ligase-like; KEGG: mmu:234814 methenyltetrahydrofolate synthetase domain containing. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
Sfum_0477 | purN-2 | Sfum_0477 | Sfum_1185 | 5-formyltetrahydrofolate cyclo-ligase-like; KEGG: mmu:234814 methenyltetrahydrofolate synthetase domain containing. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.918 |
Sfum_3083 | Sfum_0400 | Sfum_3083 | Sfum_0400 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |
Sfum_3083 | fhs | Sfum_3083 | Sfum_2687 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: dps:DP2227 probable formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.987 |
Sfum_3083 | fmt | Sfum_3083 | Sfum_0148 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.580 |
Sfum_3083 | folD | Sfum_3083 | Sfum_2686 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.978 |
Sfum_3083 | glyA | Sfum_3083 | Sfum_1377 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.987 |
Sfum_3083 | purC | Sfum_3083 | Sfum_1263 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | KEGG: gsu:GSU2091 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.934 |
Sfum_3083 | purN | Sfum_3083 | Sfum_0434 | PFAM: AICARFT/IMPCHase bienzyme, formylation region; KEGG: dps:DP1741 related to bifunctional purine biosynthesis protein (PurH). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |