node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cgtA | proA | SAR11_0222 | SAR11_0224 | GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.877 |
cgtA | ybeB | SAR11_0222 | SAR11_0226 | GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.974 |
cgtA | ybeN | SAR11_0222 | SAR11_0225 | GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.859 |
cinA | nadC | SAR11_0943 | SAR11_0619 | Competence/damage-inducible protein CinA; Belongs to the CinA family. | Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | 0.910 |
cinA | ybeN | SAR11_0943 | SAR11_0225 | Competence/damage-inducible protein CinA; Belongs to the CinA family. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.948 |
nadC | cinA | SAR11_0619 | SAR11_0943 | Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Competence/damage-inducible protein CinA; Belongs to the CinA family. | 0.910 |
nadC | ybeN | SAR11_0619 | SAR11_0225 | Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.933 |
nadE | pntA | SAR11_1149 | SAR11_0574 | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Alanine dehydrogenase/PNT; C-terminal. | 0.900 |
nadE | pntAB | SAR11_1149 | SAR11_0575 | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NAD(P) transhydrogenase subunit alpha part 2. | 0.900 |
nadE | pntB | SAR11_1149 | SAR11_0576 | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.906 |
nadE | ppnK | SAR11_1149 | SAR11_1132 | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.935 |
nadE | ybeN | SAR11_1149 | SAR11_0225 | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.937 |
pntA | nadE | SAR11_0574 | SAR11_1149 | Alanine dehydrogenase/PNT; C-terminal. | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.900 |
pntA | pntAB | SAR11_0574 | SAR11_0575 | Alanine dehydrogenase/PNT; C-terminal. | NAD(P) transhydrogenase subunit alpha part 2. | 0.999 |
pntA | pntB | SAR11_0574 | SAR11_0576 | Alanine dehydrogenase/PNT; C-terminal. | NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
pntA | ppnK | SAR11_0574 | SAR11_1132 | Alanine dehydrogenase/PNT; C-terminal. | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.909 |
pntA | ybeN | SAR11_0574 | SAR11_0225 | Alanine dehydrogenase/PNT; C-terminal. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.902 |
pntAB | nadE | SAR11_0575 | SAR11_1149 | NAD(P) transhydrogenase subunit alpha part 2. | NH(3)-dependent NAD+ synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.900 |
pntAB | pntA | SAR11_0575 | SAR11_0574 | NAD(P) transhydrogenase subunit alpha part 2. | Alanine dehydrogenase/PNT; C-terminal. | 0.999 |
pntAB | pntB | SAR11_0575 | SAR11_0576 | NAD(P) transhydrogenase subunit alpha part 2. | NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |