node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pcar_0401 | Pcar_0402 | Pcar_0401 | Pcar_0402 | HAD superfamily hydrolase. | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.760 |
Pcar_0401 | maf-1 | Pcar_0401 | Pcar_0404 | HAD superfamily hydrolase. | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.666 |
Pcar_0401 | topA | Pcar_0401 | Pcar_0406 | HAD superfamily hydrolase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.485 |
Pcar_0401 | trmFO | Pcar_0401 | Pcar_0405 | HAD superfamily hydrolase. | tRNA (5-methyl-U54)-methylenetransferase/reductase; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.659 |
Pcar_0401 | yggS | Pcar_0401 | Pcar_0403 | HAD superfamily hydrolase. | Pyridoxal-5'-phosphate-dependent enzyme, class III; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.800 |
Pcar_0402 | Pcar_0401 | Pcar_0402 | Pcar_0401 | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | HAD superfamily hydrolase. | 0.760 |
Pcar_0402 | maf-1 | Pcar_0402 | Pcar_0404 | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.627 |
Pcar_0402 | topA | Pcar_0402 | Pcar_0406 | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.461 |
Pcar_0402 | trmFO | Pcar_0402 | Pcar_0405 | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | tRNA (5-methyl-U54)-methylenetransferase/reductase; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.621 |
Pcar_0402 | yggS | Pcar_0402 | Pcar_0403 | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | Pyridoxal-5'-phosphate-dependent enzyme, class III; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.795 |
dprA | smg | Pcar_0408 | Pcar_0407 | DNA protection single-strand-binding protein DprA. | Protein of unknown function DUF494; Belongs to the Smg family. | 0.802 |
dprA | topA | Pcar_0408 | Pcar_0406 | DNA protection single-strand-binding protein DprA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.857 |
dprA | trmFO | Pcar_0408 | Pcar_0405 | DNA protection single-strand-binding protein DprA. | tRNA (5-methyl-U54)-methylenetransferase/reductase; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.474 |
maf-1 | Pcar_0401 | Pcar_0404 | Pcar_0401 | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | HAD superfamily hydrolase. | 0.666 |
maf-1 | Pcar_0402 | Pcar_0404 | Pcar_0402 | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Sodium-dependent transporter, SNF family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. | 0.627 |
maf-1 | topA | Pcar_0404 | Pcar_0406 | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.609 |
maf-1 | trmFO | Pcar_0404 | Pcar_0405 | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | tRNA (5-methyl-U54)-methylenetransferase/reductase; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.847 |
maf-1 | yggS | Pcar_0404 | Pcar_0403 | Nucleotide/nucleic acid-binding septum formation-inhibiting protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Pyridoxal-5'-phosphate-dependent enzyme, class III; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.909 |
pyrG | topA | Pcar_1945 | Pcar_0406 | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.574 |
pyrG | trmD | Pcar_1945 | Pcar_2221 | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | tRNA (N1-methyl-G37)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.611 |