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purD purD purM purM purF purF purE purE purC purC purL purL purQ purQ purS purS purB purB glyA glyA carB carB
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
purDPurD; Phosphoribosylamine-glycine ligase. (438 aa)    
Predicted Functional Partners:
purM
PurM; Phosphoribosylformylglycinamidine cyclo-ligase.
  
 0.999
purF
PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 0.999
purE
PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.999
purC
PurC; Phosphoribosylaminoimidazole-succinocarboxamide synthase; pfam01259, cd01415; Belongs to the SAICAR synthetase family.
 
 
 0.998
purL
PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule f [...]
  
 0.998
purQ
PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule f [...]
 
  
 0.997
purS
Predicted phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
  
 
 0.996
purB
PurB; Adenylosuccinate lyase; COG0015, pfam00206; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.996
glyA
GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
  
 
 0.938
carB
Carbamoyl-phosphate synthase, large chain; COG0458, pfam02786, cd01424; Belongs to the CarB family.
 
  
 0.864
Your Current Organism:
Methanosphaera stadtmanae
NCBI taxonomy Id: 339860
Other names: M. stadtmanae DSM 3091, Methanosphaera stadtmanae ATCC 43021, Methanosphaera stadtmanae DSM 3091, Methanosphaera stadtmanae MCB-3, Methanosphaera stadtmanae str. DSM 3091, Methanosphaera stadtmanae strain DSM 3091
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