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trpF trpF trpD trpD trpC trpC Pars_1422 Pars_1422 Pars_1421 Pars_1421 Pars_1420 Pars_1420 Pars_0846 Pars_0846 aroD aroD Pars_1416 Pars_1416 guaA guaA trpB trpB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: pai:PAE2499 phosphoribosyl anthranilate isomerase; Belongs to the TrpF family. (208 aa)    
Predicted Functional Partners:
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.999
trpC
PFAM: Indole-3-glycerol phosphate synthase; KEGG: pis:Pisl_0124 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family.
 
 
 0.999
Pars_1422
KEGG: pai:PAE2458 tryptophan synthase alpha subunit; TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase, alpha chain.
 
  
 0.993
Pars_1421
Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pai:PAE2459 anthranilate synthase component II.
 
  
 0.991
Pars_1420
KEGG: pai:PAE2460 anthranilate synthase component I; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I and chorismate binding protein.
 
  
 0.932
Pars_0846
PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: pis:Pisl_0268 anthranilate synthase.
 
  
 0.910
aroD
3-dehydroquinate dehydratase / chorismate mutase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
  
  
 0.812
Pars_1416
KEGG: pai:PAE2498 hypothetical protein.
       0.705
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.682
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.597
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
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