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hemL hemL Pars_2247 Pars_2247 hemA1 hemA1 hemA2 hemA2 hemC hemC Pars_2255 Pars_2255 guaA guaA Pars_2251 Pars_2251 Pars_2252 Pars_2252 Pars_2253 Pars_2253 Pars_0958 Pars_0958
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pai:PAE0594 glutamate-1-semialdehyde aminotransferase (hemL); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (423 aa)    
Predicted Functional Partners:
Pars_2247
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family.
 
 
 0.994
hemA1
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.984
hemA2
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.984
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
  
 0.913
Pars_2255
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0596 metallo cofactor biosynthesis protein.
  
  
 0.823
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.813
Pars_2251
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
     
 0.683
Pars_2252
KEGG: pai:PAE1803a hypothetical protein.
       0.655
Pars_2253
KEGG: pai:PAE1804 hypothetical protein.
       0.655
Pars_0958
PFAM: aspartate/glutamate/uridylate kinase; KEGG: pai:PAE2877 aspartate kinase.
  
  
 0.638
Your Current Organism:
Pyrobaculum arsenaticum
NCBI taxonomy Id: 340102
Other names: P. arsenaticum DSM 13514, Pyrobaculum arsenaticum DSM 13514, Pyrobaculum arsenaticum str. DSM 13514, Pyrobaculum arsenaticum strain DSM 13514
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