node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABP69184.1 | ABP70475.1 | Rsph17025_0274 | Rsph17025_1582 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. | 0.428 |
ABP69184.1 | ABP71541.1 | Rsph17025_0274 | Rsph17025_2654 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. | 0.950 |
ABP69184.1 | glyA | Rsph17025_0274 | Rsph17025_0354 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.630 |
ABP69184.1 | nadK | Rsph17025_0274 | Rsph17025_0353 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.601 |
ABP69428.1 | ABP70010.1 | Rsph17025_0522 | Rsph17025_1109 | PFAM: NUDIX hydrolase. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | 0.916 |
ABP69428.1 | ABP70474.1 | Rsph17025_0522 | Rsph17025_1581 | PFAM: NUDIX hydrolase. | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
ABP69428.1 | ABP70475.1 | Rsph17025_0522 | Rsph17025_1582 | PFAM: NUDIX hydrolase. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. | 0.900 |
ABP69428.1 | nadD | Rsph17025_0522 | Rsph17025_0489 | PFAM: NUDIX hydrolase. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.907 |
ABP69428.1 | nadE | Rsph17025_0522 | Rsph17025_1593 | PFAM: NUDIX hydrolase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.910 |
ABP69428.1 | nadK | Rsph17025_0522 | Rsph17025_0353 | PFAM: NUDIX hydrolase. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.902 |
ABP69628.1 | nadK | Rsph17025_0722 | Rsph17025_0353 | PFAM: protein of unknown function DUF1321. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.580 |
ABP70010.1 | ABP69428.1 | Rsph17025_1109 | Rsph17025_0522 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | PFAM: NUDIX hydrolase. | 0.916 |
ABP70010.1 | ABP70474.1 | Rsph17025_1109 | Rsph17025_1581 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.902 |
ABP70010.1 | ABP70475.1 | Rsph17025_1109 | Rsph17025_1582 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. | 0.900 |
ABP70010.1 | nadD | Rsph17025_1109 | Rsph17025_0489 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.903 |
ABP70010.1 | nadE | Rsph17025_1109 | Rsph17025_1593 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.900 |
ABP70010.1 | nadK | Rsph17025_1109 | Rsph17025_0353 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.905 |
ABP70474.1 | ABP69428.1 | Rsph17025_1581 | Rsph17025_0522 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | PFAM: NUDIX hydrolase. | 0.900 |
ABP70474.1 | ABP70010.1 | Rsph17025_1581 | Rsph17025_1109 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase. | 0.902 |
ABP70474.1 | ABP70475.1 | Rsph17025_1581 | Rsph17025_1582 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. | 0.999 |