STRINGSTRING
menD menD Mflv_4680 Mflv_4680 menB menB menC menC Mflv_5262 Mflv_5262 Mflv_5264 Mflv_5264 menA menA menG menG Mflv_5260 Mflv_5260 Mflv_3261 Mflv_3261 Mflv_0033 Mflv_0033
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
menD2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (545 aa)    
Predicted Functional Partners:
Mflv_4680
TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: mmc:Mmcs_1387 isochorismate synthases.
 
 0.984
menB
1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
  
 0.970
menC
Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
   
 0.956
Mflv_5262
Hypothetical protein; KEGG: mmc:Mmcs_0752 putative conserved transmembrane protein.
       0.893
Mflv_5264
PFAM: alpha/beta hydrolase fold; KEGG: mmc:Mmcs_0750 alpha/beta hydrolase fold.
  
  
 0.882
menA
1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.851
menG
Demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.834
Mflv_5260
PFAM: glycosyl transferase, group 1; KEGG: mmc:Mmcs_0761 glycosyl transferase, group 1.
     
 0.758
Mflv_3261
Hypothetical protein; KEGG: nfa:nfa55430 O-succinylbenzoate-CoA synthase.
 
   
 0.740
Mflv_0033
PFAM: AMP-dependent synthetase and ligase; KEGG: mva:Mvan_0937 AMP-dependent synthetase and ligase.
 
  
 0.630
Your Current Organism:
Mycolicibacterium gilvum
NCBI taxonomy Id: 350054
Other names: M. gilvum PYR-GCK, Mycobacterium flavescens ATCC 700033, Mycobacterium flavescens PYR-GCK, Mycobacterium gilvum PYR-GCK, Mycolicibacterium gilvum PYR-GCK
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