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mprA mprA mprB mprB Mvan_5263 Mvan_5263 Mvan_0830 Mvan_0830 Mvan_0011 Mvan_0011 Mvan_2335 Mvan_2335 Mvan_1833 Mvan_1833 Mvan_3675 Mvan_3675 Mvan_3840 Mvan_3840 Mvan_0192 Mvan_0192 Mvan_2118 Mvan_2118
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mprATwo component transcriptional regulator, winged helix family; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). (231 aa)    
Predicted Functional Partners:
mprB
Integral membrane sensor signal transduction histidine kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity).
 
 0.999
Mvan_5263
PFAM: GAF domain protein; KEGG: mmc:Mmcs_3585 putative GAF sensor protein.
  
 
 0.944
Mvan_0830
Histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_0660 histidine kinase.
 
 0.887
Mvan_0011
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_4653 periplasmic sensor signal transduction histidine kinase.
 
 
 0.885
Mvan_2335
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: cjk:jk0342 signal transduction histidine kinase.
 
 
 0.877
Mvan_1833
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_1438 periplasmic sensor signal transduction histidine kinase.
 
 0.868
Mvan_3675
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_1438 periplasmic sensor signal transduction histidine kinase.
 
 0.864
Mvan_3840
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: tfu:Tfu_1940 ATP-binding region, ATPase-like:histidine kinase, HAMP region:histidine kinase A, N-terminal.
 
 
 0.852
Mvan_0192
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_0166 periplasmic sensor signal transduction histidine kinase.
 
 
 0.851
Mvan_2118
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: mmc:Mmcs_2995 periplasmic sensor signal transduction histidine kinase.
 
 
 0.843
Your Current Organism:
Mycolicibacterium vanbaalenii
NCBI taxonomy Id: 350058
Other names: M. vanbaalenii PYR-1, Mycobacterium sp. PYR-1, Mycobacterium vanbaalenii DSM 7251, Mycobacterium vanbaalenii PYR-1, Mycolicibacterium vanbaalenii DSM 7251, Mycolicibacterium vanbaalenii PYR-1
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