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ureD-1 ureD-1 ureF1 ureF1 ureB-1 ureB-1 ureA-1 ureA-1 ureG-1 ureG-1 ureE1 ureE1 ureF2 ureF2 ureG2 ureG2 ureB2 ureB2 ureA-2 ureA-2 ureC-1 ureC-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ureD-1Urease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreD family. (280 aa)    
Predicted Functional Partners:
ureF1
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreF family.
 
 
 0.992
ureB-1
Urease, beta subunit; Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.
 
 
 0.968
ureA-1
Urease, gamma subunit; Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.
 
 
 0.967
ureG-1
Urease accessory protein UreG 1; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG; Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
 
 
 0.966
ureE1
UreE urease accessory, N-terminal:UreE urease accessory, C-terminal; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
 
  
 0.956
ureF2
UreE urease accessory, N-terminal; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter; Belongs to the UreF family.
  
 
 0.929
ureG2
Urease accessory protein UreG 2; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
 
 0.899
ureB2
Urease, beta subunit; Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.
 
 
 0.889
ureA-2
Urease, gamma subunit; Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.
 
 
 0.881
ureC-1
Urease:Amidohydrolase; May protect brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
 
  
 0.843
Your Current Organism:
Brucella abortus
NCBI taxonomy Id: 359391
Other names: B. abortus 2308, Brucella abortus 2308, Brucella melitensis biovar Abortus 2308
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