node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT99845.1 | clpX | CCV52592_0971 | CCV52592_0867 | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | ATP-dependent ClpXP protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.454 |
EAT99845.1 | lpxA | CCV52592_0971 | CCV52592_0866 | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.853 |
EAT99845.1 | lpxB | CCV52592_0971 | CCV52592_1652 | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.566 |
EAT99845.1 | lpxD | CCV52592_0971 | CCV52592_1430 | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.567 |
EAT99845.1 | murA | CCV52592_0971 | CCV52592_1092 | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | UDP-N-acetylglucosamine enolpyruvoyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.412 |
EAU00925.1 | glmU | CCV52592_1221 | CCV52592_1268 | Polysaccharide biosynthesis protein, nucleotide sugar dehydrogenase, TviB family; Pfam matches to PF03721.9 UDPG_MGDP_dh_N, and to PF00984.14 UDPG_MGDP_dh, and to PF03720.10 UDPG_MGDP_dh_C, and to PF03446.10 NAD_binding_2, and to PF01210.18 NAD_Gly3P_dh_N; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.923 |
EAU00925.1 | lpxA | CCV52592_1221 | CCV52592_0866 | Polysaccharide biosynthesis protein, nucleotide sugar dehydrogenase, TviB family; Pfam matches to PF03721.9 UDPG_MGDP_dh_N, and to PF00984.14 UDPG_MGDP_dh, and to PF03720.10 UDPG_MGDP_dh_C, and to PF03446.10 NAD_binding_2, and to PF01210.18 NAD_Gly3P_dh_N; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.823 |
EAU00925.1 | murA | CCV52592_1221 | CCV52592_1092 | Polysaccharide biosynthesis protein, nucleotide sugar dehydrogenase, TviB family; Pfam matches to PF03721.9 UDPG_MGDP_dh_N, and to PF00984.14 UDPG_MGDP_dh, and to PF03720.10 UDPG_MGDP_dh_C, and to PF03446.10 NAD_binding_2, and to PF01210.18 NAD_Gly3P_dh_N; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine enolpyruvoyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.903 |
clpX | EAT99845.1 | CCV52592_0867 | CCV52592_0971 | ATP-dependent ClpXP protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | acyl-CoA synthetase / AMP-(fatty) acid ligase; Pfam match to PF00501.23 AMP-binding. | 0.454 |
clpX | fabZ | CCV52592_0867 | CCV52592_0865 | ATP-dependent ClpXP protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | 0.788 |
clpX | lpxA | CCV52592_0867 | CCV52592_0866 | ATP-dependent ClpXP protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.824 |
fabZ | clpX | CCV52592_0865 | CCV52592_0867 | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | ATP-dependent ClpXP protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.788 |
fabZ | lpxA | CCV52592_0865 | CCV52592_0866 | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.987 |
fabZ | lpxB | CCV52592_0865 | CCV52592_1652 | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.543 |
fabZ | lpxC | CCV52592_0865 | CCV52592_1101 | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.934 |
fabZ | lpxD | CCV52592_0865 | CCV52592_1430 | 3-hydroxyacyl-[acp] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. | UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.796 |
glmU | EAU00925.1 | CCV52592_1268 | CCV52592_1221 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | Polysaccharide biosynthesis protein, nucleotide sugar dehydrogenase, TviB family; Pfam matches to PF03721.9 UDPG_MGDP_dh_N, and to PF00984.14 UDPG_MGDP_dh, and to PF03720.10 UDPG_MGDP_dh_C, and to PF03446.10 NAD_binding_2, and to PF01210.18 NAD_Gly3P_dh_N; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.923 |
glmU | lpxA | CCV52592_1268 | CCV52592_0866 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.843 |
glmU | murA | CCV52592_1268 | CCV52592_1092 | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | UDP-N-acetylglucosamine enolpyruvoyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.948 |
kdtA | lpxA | CCV52592_0673 | CCV52592_0866 | 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.842 |