node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fhs | folC | LI0874 | LI0131 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.717 |
fhs | folD | LI0874 | LI0875 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.990 |
fhs | glyA | LI0874 | LI0159 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Deoxycytidylate deaminase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.701 |
fhs | guaA | LI0874 | LI0590 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.708 |
fhs | purC | LI0874 | LI0349 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. | 0.841 |
fhs | purF | LI0874 | LI0938 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.723 |
fhs | purH | LI0874 | LI0200 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | AICAR transformylase/IMP cyclohydrolase PurH. | 0.648 |
fhs | purL-2 | LI0874 | LI0516 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] | 0.972 |
fhs | purN | LI0874 | LI0118 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.686 |
fhs | rsmH | LI0874 | LI1097 | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.751 |
folC | fhs | LI0131 | LI0874 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.717 |
folC | folD | LI0131 | LI0875 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.781 |
folC | glyA | LI0131 | LI0159 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Deoxycytidylate deaminase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.733 |
folC | guaA | LI0131 | LI0590 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.568 |
folC | purF | LI0131 | LI0938 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.455 |
folC | purN | LI0131 | LI0118 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.411 |
folD | fhs | LI0875 | LI0874 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Fthfsdc1 protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.990 |
folD | folC | LI0875 | LI0131 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.781 |
folD | glyA | LI0875 | LI0159 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Deoxycytidylate deaminase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
folD | guaA | LI0875 | LI0590 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | GMP synthase-Glutamine amidotransferase domain; Catalyzes the synthesis of GMP from XMP. | 0.619 |