node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Smed_1135 | mraY | Smed_1135 | Smed_2085 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.575 |
Smed_1135 | pheT | Smed_1135 | Smed_3487 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: sme:SMc00366 probable phenylalanyl-tRNA synthetase beta chain protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.489 |
Smed_1135 | uppP | Smed_1135 | Smed_3536 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.934 |
Smed_3533 | Smed_3535 | Smed_3533 | Smed_3535 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: sme:SMc00405 hypothetical protein. | PFAM: Glutathione S-transferase domain; KEGG: sme:SMc00407 putative glutathione S-transferase protein. | 0.844 |
Smed_3533 | queG | Smed_3533 | Smed_3534 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: sme:SMc00405 hypothetical protein. | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.800 |
Smed_3533 | uppP | Smed_3533 | Smed_3536 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: sme:SMc00405 hypothetical protein. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.573 |
Smed_3535 | Smed_3533 | Smed_3535 | Smed_3533 | PFAM: Glutathione S-transferase domain; KEGG: sme:SMc00407 putative glutathione S-transferase protein. | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: sme:SMc00405 hypothetical protein. | 0.844 |
Smed_3535 | queG | Smed_3535 | Smed_3534 | PFAM: Glutathione S-transferase domain; KEGG: sme:SMc00407 putative glutathione S-transferase protein. | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.795 |
Smed_3535 | uppP | Smed_3535 | Smed_3536 | PFAM: Glutathione S-transferase domain; KEGG: sme:SMc00407 putative glutathione S-transferase protein. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.577 |
glmU | uppP | Smed_1405 | Smed_3536 | Nucleotidyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.444 |
mraY | Smed_1135 | Smed_2085 | Smed_1135 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.575 |
mraY | uppP | Smed_2085 | Smed_3536 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.924 |
pheT | Smed_1135 | Smed_3487 | Smed_1135 | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: sme:SMc00366 probable phenylalanyl-tRNA synthetase beta chain protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.489 |
pheT | rsmA | Smed_3487 | Smed_0760 | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: sme:SMc00366 probable phenylalanyl-tRNA synthetase beta chain protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.642 |
pheT | uppP | Smed_3487 | Smed_3536 | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: sme:SMc00366 probable phenylalanyl-tRNA synthetase beta chain protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.429 |
queA | queG | Smed_1267 | Smed_3534 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | 0.832 |
queA | tgt | Smed_1267 | Smed_1268 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.996 |
queA | uppP | Smed_1267 | Smed_3536 | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.512 |
queG | Smed_3533 | Smed_3534 | Smed_3533 | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: sme:SMc00405 hypothetical protein. | 0.800 |
queG | Smed_3535 | Smed_3534 | Smed_3535 | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. | PFAM: Glutathione S-transferase domain; KEGG: sme:SMc00407 putative glutathione S-transferase protein. | 0.795 |