STRINGSTRING
ppcA ppcA Tpen_0588 Tpen_0588 pckG pckG Tpen_0119 Tpen_0119 Tpen_0330 Tpen_0330 eno eno Tpen_1408 Tpen_1408 Tpen_0189 Tpen_0189 Tpen_1409 Tpen_1409 Tpen_1410 Tpen_1410 Tpen_1266 Tpen_1266
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (464 aa)    
Predicted Functional Partners:
Tpen_0588
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.929
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.927
Tpen_0119
Pyruvate carboxylase subunit A; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: mja:MJ1229 pyruvate carboxylase subunit A.
     
 0.922
Tpen_0330
PFAM: pyruvate kinase; KEGG: art:Arth_1693 pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.904
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
Tpen_1408
Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2662 formate dehydrogenase alpha subunit.
  
  
  0.872
Tpen_0189
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tko:TK2077 4Fe-4S cluster-binding protein.
     
  0.800
Tpen_1409
PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE2661 formate dehydrogenase beta subunit.
     
  0.800
Tpen_1410
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
     
  0.800
Tpen_1266
Hypothetical protein.
       0.601
Your Current Organism:
Thermofilum pendens
NCBI taxonomy Id: 368408
Other names: T. pendens Hrk 5, Thermofilum pendens Hrk 5, Thermofilum pendens str. Hrk 5, Thermofilum pendens strain Hrk 5
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