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hemL hemL hemB hemB hemA hemA hemC hemC nrpB nrpB h16_B1683 h16_B1683 nrpC nrpC hemE hemE nirE nirE cysG cysG fabF fabF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
hemLGlutamate-1-semialdehyde 2,1-aminomutase. (430 aa)    
Predicted Functional Partners:
hemB
Porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.994
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.990
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.961
nrpB
Non-ribosomal peptide synthetase.
  
 
 0.950
h16_B1683
Non-ribosomal peptide synthetase modules and related proteins; Belongs to the ATP-dependent AMP-binding enzyme family.
 
  
 0.913
nrpC
Non-ribosomal peptide synthetase.
 
  
 0.876
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.796
nirE
Uroporphyrin-III C-methyltransferase.
 
   
 0.789
cysG
Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
   
 0.782
fabF
3-Oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
  
 0.655
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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