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h16_A2814 h16_A2814 kynU kynU tdo1 tdo1 tdo2 tdo2 h16_B1997 h16_B1997 fmdA1 fmdA1 aimE aimE aceB aceB fumA fumA pyc pyc mdh1 mdh1
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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h16_A2814Predicted metal-dependent hydrolase/Putative cyclase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (216 aa)    
Predicted Functional Partners:
kynU
L-Kynurenine hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.
 
 
 0.999
tdo1
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
 
 
 0.999
tdo2
Tryptophan 2,3-dioxygenase.
 
 
 0.986
h16_B1997
Putative aylformamidase.
    
  0.900
fmdA1
Formamidase.
  
  
  0.822
aimE
Aliphatic amidase; Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
    
 0.819
aceB
Malate synthase; Belongs to the malate synthase family.
   
 
  0.808
fumA
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.807
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.806
mdh1
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
    
  0.801
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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