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pdxT pdxT pdxS pdxS Pisl_1117 Pisl_1117 Pisl_1200 Pisl_1200 Pisl_0380 Pisl_0380 Pisl_1775 Pisl_1775 Pisl_1776 Pisl_1776 Pisl_1337 Pisl_1337 guaA guaA gatD gatD gatE gatE
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
pdxTPyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (202 aa)    
Predicted Functional Partners:
pdxS
Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
 
 0.999
Pisl_1117
PFAM: PfkB domain protein; KEGG: pai:PAE0835 sugar kinase, possible phosphofructokinase; Belongs to the carbohydrate kinase PfkB family.
     
 0.837
Pisl_1200
KEGG: pai:PAE1027 ribose 5-phosphate isomerase; TIGRFAM: ribose 5-phosphate isomerase; PFAM: Ribose 5-phosphate isomerase.
     
 0.802
Pisl_0380
KEGG: pai:PAE2980 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family.
    
  0.801
Pisl_1775
Transketolase subunit B; PFAM: Transketolase, central region; Transketolase domain protein; KEGG: pai:PAE1927 transketolase (C terminal section).
     
  0.800
Pisl_1776
PFAM: Transketolase domain protein; KEGG: pai:PAE1929 transketolase (N terminal section).
     
  0.800
Pisl_1337
Protein of unknown function DUF650; Involved in DNA damage repair.
       0.678
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.572
gatD
glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
    
  0.510
gatE
glutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
     
  0.499
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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