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hemL hemL hemB hemB hemA hemA hemC hemC PSEEN5536 PSEEN5536 PSEEN2150 PSEEN2150 thiE thiE PSEEN2153 PSEEN2153 PSEEN5531 PSEEN5531 PSEEN3232 PSEEN3232 thiD thiD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hemLGlutamate-1-semialdehyde aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (427 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Function of strongly homologous gene; enzyme; Belongs to the ALAD family.
 
 
 0.993
hemA
Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.989
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.931
PSEEN5536
Putative polyketide synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
    
 0.905
PSEEN2150
Putative non-ribosomal peptide synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 
 0.896
thiE
Thiamin-phosphate pyrophosphorylase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
 0.894
PSEEN2153
Putative polyketide synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
    
 0.872
PSEEN5531
Putative polyketide synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
  
 0.838
PSEEN3232
Putative pyoverdine sidechain peptide synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 
 0.814
thiD
Phosphomethylpyrimidine kinase ThiD; Function of strongly homologous gene; enzyme.
  
  
 0.784
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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