node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ftsH | hisA | SUN_1953 | SUN_1951 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.804 |
ftsH | hisH | SUN_1953 | SUN_1950 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.692 |
ftsH | prmA | SUN_1953 | SUN_1952 | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.816 |
guaA | hisA | SUN_1897 | SUN_1951 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.817 |
guaA | hisF | SUN_1897 | SUN_2367 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.488 |
guaA | hisH | SUN_1897 | SUN_1950 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.511 |
hisA | ftsH | SUN_1951 | SUN_1953 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.804 |
hisA | guaA | SUN_1951 | SUN_1897 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.817 |
hisA | hisB | SUN_1951 | SUN_1227 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | 0.969 |
hisA | hisC | SUN_1951 | SUN_2056 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.906 |
hisA | hisD | SUN_1951 | SUN_1800 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.971 |
hisA | hisF | SUN_1951 | SUN_2367 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.991 |
hisA | hisG | SUN_1951 | SUN_0424 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.964 |
hisA | hisH | SUN_1951 | SUN_1950 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SUN_1951 | SUN_0237 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | prmA | SUN_1951 | SUN_1952 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 0.800 |
hisB | hisA | SUN_1227 | SUN_1951 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide. | 0.969 |
hisB | hisC | SUN_1227 | SUN_2056 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SUN_1227 | SUN_1800 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisB | hisF | SUN_1227 | SUN_2367 | Imidazoleglycerol-phosphate dehydratase; C terminus of bifunctional HisB protein, histidinol-phosphatase EC 3.1.3.15, N-terminal/imidazoleglycerol-phosphate dehydratase EC 4.2.1.19, C-terminal. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |