node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACA70871.1 | murI | PputW619_0365 | PputW619_4453 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.931 |
ACA70896.1 | ACA71026.1 | PputW619_0390 | PputW619_0521 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.935 |
ACA70896.1 | ACA72458.1 | PputW619_0390 | PputW619_1955 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | 0.921 |
ACA70896.1 | murD | PputW619_0390 | PputW619_0942 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.534 |
ACA70896.1 | murI | PputW619_0390 | PputW619_4453 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.782 |
ACA71026.1 | ACA70896.1 | PputW619_0521 | PputW619_0390 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | 0.935 |
ACA71026.1 | ACA72458.1 | PputW619_0521 | PputW619_1955 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | 0.948 |
ACA71026.1 | murI | PputW619_0521 | PputW619_4453 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.736 |
ACA72458.1 | ACA70896.1 | PputW619_1955 | PputW619_0390 | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: pen:PSEEN0337 glutamate synthase [NADPH] large chain precursor (GOGAT). | 0.921 |
ACA72458.1 | ACA71026.1 | PputW619_1955 | PputW619_0521 | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.948 |
ACA72458.1 | murD | PputW619_1955 | PputW619_0942 | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.900 |
ACA72458.1 | murI | PputW619_1955 | PputW619_4453 | L-asparaginase, type II; KEGG: pen:PSEEN1951 glutaminase-asparaginase; TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; Belongs to the asparaginase 1 family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.905 |
ACA74934.1 | hemA | PputW619_4454 | PputW619_4457 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pen:PSEEN0878 molybdopterin biosynthesis MoeB protein. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.822 |
ACA74934.1 | murI | PputW619_4454 | PputW619_4453 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pen:PSEEN0878 molybdopterin biosynthesis MoeB protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.808 |
ACA74934.1 | prfA | PputW619_4454 | PputW619_4456 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pen:PSEEN0878 molybdopterin biosynthesis MoeB protein. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.820 |
ACA74934.1 | prmC | PputW619_4454 | PputW619_4455 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pen:PSEEN0878 molybdopterin biosynthesis MoeB protein. | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.808 |
hemA | ACA74934.1 | PputW619_4457 | PputW619_4454 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pen:PSEEN0878 molybdopterin biosynthesis MoeB protein. | 0.822 |
hemA | murI | PputW619_4457 | PputW619_4453 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.808 |
hemA | prfA | PputW619_4457 | PputW619_4456 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.871 |
hemA | prmC | PputW619_4457 | PputW619_4455 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.828 |