node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP25285.1 | fhs | NGR_c15170 | NGR_c23560 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.468 |
ACP25285.1 | folD2 | NGR_c15170 | NGR_c03080 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Bifunctional protein FolD2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.834 |
ACP25285.1 | glyA | NGR_c15170 | NGR_c09570 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.831 |
ACP25285.1 | guaB | NGR_c15170 | NGR_c03770 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.832 |
ACP25285.1 | purA | NGR_c15170 | NGR_c27680 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.995 |
ACP25285.1 | purD | NGR_c15170 | NGR_c04740 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine--glycine ligase; GARS; glycinamideribonucleotide synthetase; phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.861 |
ACP25285.1 | purF | NGR_c15170 | NGR_c08750 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.888 |
ACP25285.1 | purH | NGR_c15170 | NGR_c33280 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Bifunctional purine biosynthesis protein PurH;includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. | 0.985 |
ACP25285.1 | purM | NGR_c15170 | NGR_c09330 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylformylglycinamidine cyclo-ligase; AIRS; Phosphoribosyl-aminoimidazole synthetase; AIR synthase. | 0.856 |
ACP25285.1 | purN | NGR_c15170 | NGR_c09320 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Putative 5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.861 |
fhs | ACP25285.1 | NGR_c23560 | NGR_c15170 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.468 |
fhs | folD2 | NGR_c23560 | NGR_c03080 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolD2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | NGR_c23560 | NGR_c09570 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
fhs | purD | NGR_c23560 | NGR_c04740 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; GARS; glycinamideribonucleotide synthetase; phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.699 |
fhs | purF | NGR_c23560 | NGR_c08750 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.849 |
fhs | purH | NGR_c23560 | NGR_c33280 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH;includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. | 0.987 |
fhs | purM | NGR_c23560 | NGR_c09330 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine cyclo-ligase; AIRS; Phosphoribosyl-aminoimidazole synthetase; AIR synthase. | 0.427 |
fhs | purN | NGR_c23560 | NGR_c09320 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.969 |
folD2 | ACP25285.1 | NGR_c03080 | NGR_c15170 | Bifunctional protein FolD2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.834 |
folD2 | fhs | NGR_c03080 | NGR_c23560 | Bifunctional protein FolD2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |