node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aave_1546 | hisA | Aave_1546 | Aave_1034 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.849 |
Aave_1546 | hisB | Aave_1546 | Aave_1032 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pol:Bpro_0806 imidazoleglycerol-phosphate dehydratase. | 0.984 |
Aave_1546 | hisC | Aave_1546 | Aave_1031 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2947 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.900 |
Aave_1546 | hisD | Aave_1546 | Aave_1024 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.854 |
Aave_1546 | hisE | Aave_1546 | Aave_1049 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pol:Bpro_0811 phosphoribosyl-ATP pyrophosphohydrolase. | 0.794 |
Aave_1546 | hisF | Aave_1546 | Aave_1047 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.856 |
Aave_1546 | hisG | Aave_1546 | Aave_1023 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.829 |
Aave_1546 | hisH | Aave_1546 | Aave_1033 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.856 |
Aave_1546 | hisI | Aave_1546 | Aave_1048 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.859 |
Aave_1546 | hisZ | Aave_1546 | Aave_1433 | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.744 |
hisA | Aave_1546 | Aave_1034 | Aave_1546 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2615 aminotransferase, class I and II. | 0.849 |
hisA | hisB | Aave_1034 | Aave_1032 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pol:Bpro_0806 imidazoleglycerol-phosphate dehydratase. | 0.997 |
hisA | hisC | Aave_1034 | Aave_1031 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: rfr:Rfer_2947 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.969 |
hisA | hisD | Aave_1034 | Aave_1024 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisE | Aave_1034 | Aave_1049 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pol:Bpro_0811 phosphoribosyl-ATP pyrophosphohydrolase. | 0.990 |
hisA | hisF | Aave_1034 | Aave_1047 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisG | Aave_1034 | Aave_1023 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.988 |
hisA | hisH | Aave_1034 | Aave_1033 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Aave_1034 | Aave_1048 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Aave_1034 | Aave_1433 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: pol:Bpro_0808 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.930 |