STRINGSTRING
aceK aceK Aave_2572 Aave_2572 Aave_2860 Aave_2860 Aave_4368 Aave_4368 Aave_4370 Aave_4370 Aave_4367 Aave_4367 Aave_4371 Aave_4371 Aave_4366 Aave_4366 Aave_4372 Aave_4372 glcB glcB Aave_4365 Aave_4365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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aceKIsocitrate dehydrogenase kinasephosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (602 aa)    
Predicted Functional Partners:
Aave_2572
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pol:Bpro_2942 isocitrate dehydrogenase, NADP-dependent.
 
 
 
 0.917
Aave_2860
TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: dar:Daro_3098 isocitrate lyase.
 
  
 0.849
Aave_4368
KEGG: pol:Bpro_4187 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
       0.724
Aave_4370
Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.
       0.693
Aave_4367
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pol:Bpro_4186 short-chain dehydrogenase/reductase SDR.
       0.629
Aave_4371
PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain; KEGG: pol:Bpro_4190 acyl-CoA dehydrogenase-like.
       0.570
Aave_4366
PFAM: acyltransferase 3; KEGG: mxa:MXAN_1041 acyltransferase family protein.
       0.553
Aave_4372
PFAM: regulatory protein, MerR; KEGG: rfr:Rfer_3843 transcriptional regulator, MerR family.
       0.448
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
  
  
 0.439
Aave_4365
PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain; KEGG: rfr:Rfer_3838 acyl-CoA dehydrogenase-like.
       0.434
Your Current Organism:
Acidovorax citrulli
NCBI taxonomy Id: 397945
Other names: A. citrulli AAC00-1, Acidovorax avenae subsp. citrulli AAC00-1, Acidovorax citrulli AAC00-1, Acidovorax citrulli str. AAC00-1, Acidovorax citrulli strain AAC00-1
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