node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spea_0560 | Spea_1682 | Spea_0560 | Spea_1682 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.985 |
Spea_0560 | Spea_2347 | Spea_0560 | Spea_2347 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sbm:Shew185_2117 pyridoxal-5'-phosphate-dependent protein beta subunit. | 0.974 |
Spea_0560 | Spea_2520 | Spea_0560 | Spea_2520 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | KEGG: slo:Shew_1789 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.934 |
Spea_0560 | Spea_3384 | Spea_0560 | Spea_3384 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.979 |
Spea_0560 | Spea_3401 | Spea_0560 | Spea_3401 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | Adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; alanine dehydrogenase/PNT domain protein; Acetohydroxy acid isomeroreductase catalytic domain protein; S-adenosyl-L-homocysteine hydrolase, NAD binding; KEGG: mja:MJ1388 S-adenosyl-L-homocysteine hydrolase. | 0.923 |
Spea_0560 | luxS | Spea_0560 | Spea_3104 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.947 |
Spea_0560 | metE | Spea_0560 | Spea_3202 | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.965 |
Spea_1564 | Spea_3401 | Spea_1564 | Spea_3401 | Purine or other phosphorylase family 1; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | Adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; alanine dehydrogenase/PNT domain protein; Acetohydroxy acid isomeroreductase catalytic domain protein; S-adenosyl-L-homocysteine hydrolase, NAD binding; KEGG: mja:MJ1388 S-adenosyl-L-homocysteine hydrolase. | 0.914 |
Spea_1564 | Spea_3850 | Spea_1564 | Spea_3850 | Purine or other phosphorylase family 1; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | PFAM: purine or other phosphorylase family 1; KEGG: son:SO_3705 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase, putative. | 0.926 |
Spea_1564 | luxS | Spea_1564 | Spea_3104 | Purine or other phosphorylase family 1; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.981 |
Spea_1564 | mtnN | Spea_1564 | Spea_1001 | Purine or other phosphorylase family 1; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.912 |
Spea_1682 | Spea_0560 | Spea_1682 | Spea_0560 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.985 |
Spea_1682 | Spea_2347 | Spea_1682 | Spea_2347 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sbm:Shew185_2117 pyridoxal-5'-phosphate-dependent protein beta subunit. | 0.910 |
Spea_1682 | Spea_2520 | Spea_1682 | Spea_2520 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | KEGG: slo:Shew_1789 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.977 |
Spea_1682 | Spea_3384 | Spea_1682 | Spea_3384 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.886 |
Spea_1682 | Spea_3401 | Spea_1682 | Spea_3401 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; alanine dehydrogenase/PNT domain protein; Acetohydroxy acid isomeroreductase catalytic domain protein; S-adenosyl-L-homocysteine hydrolase, NAD binding; KEGG: mja:MJ1388 S-adenosyl-L-homocysteine hydrolase. | 0.857 |
Spea_1682 | luxS | Spea_1682 | Spea_3104 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.870 |
Spea_1682 | metE | Spea_1682 | Spea_3202 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.834 |
Spea_2347 | Spea_0560 | Spea_2347 | Spea_0560 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sbm:Shew185_2117 pyridoxal-5'-phosphate-dependent protein beta subunit. | KEGG: she:Shewmr4_3439 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. | 0.974 |
Spea_2347 | Spea_1682 | Spea_2347 | Spea_1682 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: sbm:Shew185_2117 pyridoxal-5'-phosphate-dependent protein beta subunit. | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: slo:Shew_2382 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.910 |