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patA patA speE speE patD patD speB speB ABP59411.1 ABP59411.1 ABP59886.1 ABP59886.1 ABP62042.1 ABP62042.1 ABP60605.1 ABP60605.1 bioB bioB bioD bioD bioD-2 bioD-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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patADiamine aminotransferase apoenzyme; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (459 aa)    
Predicted Functional Partners:
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
  
  
  0.911
patD
Betaine-aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
   
 0.903
speB
Agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily.
   
 
  0.902
ABP59411.1
PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: stm:STM0234 lysine decarboxylase 2.
     
 0.901
ABP59886.1
PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: sec:SC0721 ornithine decarboxylase isozyme, inducible.
     
 0.901
ABP62042.1
PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: ecs:ECs3841 ornithine decarboxylase isozyme.
     
 0.901
ABP60605.1
PFAM: GCN5-related N-acetyltransferase; KEGG: ecv:APECO1_667 spermidine N1-acetyltransferase.
     
  0.900
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.699
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family.
 
  
 0.575
bioD-2
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family.
  
  
 0.575
Your Current Organism:
Enterobacter sp. 638
NCBI taxonomy Id: 399742
Other names: E. sp. 638
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