node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABX22300.1 | dut | SARI_02439 | SARI_03910 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
ABX22300.1 | surE | SARI_02439 | SARI_00029 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.910 |
ABX22300.1 | tdk | SARI_02439 | SARI_01203 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; KEGG: stt:t1661 1.1e-104 tdk; thymidine kinase K00857; COG: COG1435 Thymidine kinase. | 0.925 |
ABX22300.1 | thyA | SARI_02439 | SARI_04659 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
ABX22300.1 | tmk | SARI_02439 | SARI_01792 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.910 |
ABX22300.1 | yfbR | SARI_02439 | SARI_00568 | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | Hypothetical protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | 0.910 |
ABX23037.1 | dcd | SARI_03201 | SARI_00775 | Hypothetical protein; KEGG: stm:STM4452 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | 0.902 |
ABX23037.1 | dut | SARI_03201 | SARI_03910 | Hypothetical protein; KEGG: stm:STM4452 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.916 |
ABX23037.1 | ndk | SARI_03201 | SARI_00351 | Hypothetical protein; KEGG: stm:STM4452 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96. | Hypothetical protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.910 |
ABX23705.1 | dut | SARI_03911 | SARI_03910 | Hypothetical protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.971 |
dcd | ABX23037.1 | SARI_00775 | SARI_03201 | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | Hypothetical protein; KEGG: stm:STM4452 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96. | 0.902 |
dcd | dut | SARI_00775 | SARI_03910 | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.928 |
dcd | ndk | SARI_00775 | SARI_00351 | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | Hypothetical protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
dcd | thyA | SARI_00775 | SARI_04659 | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.473 |
dcd | tmk | SARI_00775 | SARI_01792 | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | Hypothetical protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.400 |
dut | ABX22300.1 | SARI_03910 | SARI_02439 | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Hypothetical protein; KEGG: sec:SC0536 2.4e-295 ushA; UDP-sugar hydrolase 5'-nucleotidase K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score:10.00; Belongs to the 5'-nucleotidase family. | 0.900 |
dut | ABX23037.1 | SARI_03910 | SARI_03201 | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Hypothetical protein; KEGG: stm:STM4452 0. nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score:8.96. | 0.916 |
dut | ABX23705.1 | SARI_03910 | SARI_03911 | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Hypothetical protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.971 |
dut | dcd | SARI_03910 | SARI_00775 | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Hypothetical protein; Catalyzes the deamination of dCTP to dUTP. | 0.928 |
dut | ndk | SARI_03910 | SARI_00351 | Hypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Hypothetical protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.932 |