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pfk pfk pgiA pgiA pyk pyk fbaA fbaA tpiA tpiA guaA guaA enoA enoA tkt tkt fbp fbp fruC fruC mtlD mtlD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
pfkPfk protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (340 aa)    
Predicted Functional Partners:
pgiA
PgiA protein; PF00342: Phosphoglucose isomerase; High confidence in function and specificity; Belongs to the GPI family.
  
 0.995
pyk
Pyk protein; High confidence in function and specificity; Belongs to the pyruvate kinase family.
 
 0.988
fbaA
Pseudogene; Transposase for insertion sequence element IS905M, contains a stop codon at position 606; Conserved hypothetical protein.
 
 
 0.982
tpiA
TpiA protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
  
 0.978
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.965
enoA
EnoA protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.948
tkt
Tkt protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.943
fbp
Fructose-bisphosphatase; High confidence in function and specificity.
     
 0.942
fruC
Fructose 1-phosphate kinase; High confidence in function and specificity; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
  
 0.935
mtlD
Mannitol-1-phosphate 5-dehydrogenase; High confidence in function and specificity.
    
 0.920
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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