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gadB gadB gadC gadC gadR gadR gltB gltB glnA glnA purQ purQ gltD gltD arcA arcA proA proA pdhD pdhD llmg_0077 llmg_0077
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
gadBGlutamate decarboxylase; Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance; Belongs to the group II decarboxylase family. (466 aa)    
Predicted Functional Partners:
gadC
Putative glutamate/gamma-aminobutyrate antiporter; Involved in glutamate-dependent acid resistance. May be involved in antiport of glutamate and glutamate-gamma-aminobutyrate (GABA).
 
  
 0.997
gadR
Positive regulator GadR; Activates chloride dependent transcription of gadCB, TIGR01716: Transcriptional activator Rgg/GadR/MutR, C-terminal domain; High confidence in function and specificity.
     
 0.977
gltB
Glutamate synthase, large subunit; PF01645: Conserved region in glutamate synthase; High confidence in function and specificity.
    
 0.961
glnA
GlnA protein; PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity.
  
 
 0.926
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
     
  0.900
gltD
TIGR01317: glutamate synthases, NADH/NADPH, small subunit; High confidence in function and specificity.
     
  0.900
arcA
ArcA protein; PF02274: Amidinotransferase, TIGR01078: arginine deiminase; High confidence in function and specificity.
   
  
 0.863
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
    
 0.814
pdhD
Pyruvate dehydrogenase complex E3 component; lipoamide_DH: dihydrolipoamide dehydrogenase; High confidence in function and specificity.
   
 
 0.812
llmg_0077
Metal-dependent phosphohydrolase, HD region; Family membership.
 
    
 0.676
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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