node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cmhR | fhs | llmg_0947 | llmg_1595 | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.755 |
cmhR | folD | llmg_0947 | llmg_1693 | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.879 |
cmhR | metE | llmg_0947 | llmg_1225 | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.793 |
cmhR | pfs | llmg_0947 | llmg_2073 | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.911 |
dfrA | fhs | llmg_1342 | llmg_1595 | DfrA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.918 |
dfrA | glyA | llmg_1342 | llmg_0563 | DfrA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
dfrA | purH | llmg_1342 | llmg_0994 | DfrA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.924 |
dfrA | purN | llmg_1342 | llmg_0988 | DfrA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.924 |
fhs | cmhR | llmg_1595 | llmg_0947 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | 0.755 |
fhs | dfrA | llmg_1595 | llmg_1342 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | DfrA protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.918 |
fhs | folD | llmg_1595 | llmg_1693 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.999 |
fhs | glyA | llmg_1595 | llmg_0563 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
fhs | guaA | llmg_1595 | llmg_1008 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.830 |
fhs | metE | llmg_1595 | llmg_1225 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.758 |
fhs | pfs | llmg_1595 | llmg_2073 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.795 |
fhs | purC | llmg_1595 | llmg_0973 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; High confidence in function and specificity; Belongs to the SAICAR synthetase family. | 0.781 |
fhs | purH | llmg_1595 | llmg_0994 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; High confidence in function and specificity. | 0.981 |
fhs | purN | llmg_1595 | llmg_0988 | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.968 |
folD | cmhR | llmg_1693 | llmg_0947 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. | 0.879 |
folD | fhs | llmg_1693 | llmg_1595 | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. | 0.999 |