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cofC cofC cofD cofD Msm_0975 Msm_0975 Msm_0289 Msm_0289 proS proS mer mer cofG cofG Msm_0049 Msm_0049 cofH cofH Msm_0285 Msm_0285 egsA egsA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
cofCConserved hypothetical protein Msm_0288; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (224 aa)    
Predicted Functional Partners:
cofD
LPPG:FO 2-phospho-L-lactate transferase, CofD; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
  
 0.994
Msm_0975
F420-0:gamma-glutamyl ligase, CofE; COG1478.
 
   
 0.908
Msm_0289
Phosphomethylpyrimidine kinase (HMPP-kinase), ThiD; COG0351.
       0.884
proS
prolyl-tRNA synthetase, ProS; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
       0.871
mer
Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase, Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
 
   
 0.847
cofG
FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis); Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
   
 0.821
Msm_0049
F420-dependent NADP oxidoreductase, fno; COG2085.
 
   
 0.724
cofH
CofH protein (7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO)/F420 biosynthesis); Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
 
   
 0.689
Msm_0285
Conserved hypothetical protein Msm_0285; COG1860; Belongs to the UPF0179 family.
       0.528
egsA
Glycerol 1-phosphate dehydrogenase (Dehydroquinate synthase-like family); Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
       0.528
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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