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surE surE guaAB guaAB Msm_1151 Msm_1151 hpt hpt pyrH pyrH guaAA guaAA guaB guaB Msm_1734 Msm_1734 Msm_1617 Msm_1617 purA purA Msm_0398 Msm_0398
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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surEPredicted acid phosphatase (survival protein), SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa)    
Predicted Functional Partners:
guaAB
GMP synthase (glutamine-hydrolysing), PP-ATPase domain/subunit, GuaA; Catalyzes the synthesis of GMP from XMP.
    
 0.951
Msm_1151
Adenylosuccinate lyase, PurB; COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.945
hpt
Adenine phosphoribosyltransferase, Apt; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
    
 0.942
pyrH
Uridylate kinase, PyrH; Catalyzes the reversible phosphorylation of UMP to UDP.
 
  
 0.940
guaAA
GMP synthase (glutamine-hydrolysing), subunit A, GuaA; Catalyzes the synthesis of GMP from XMP.
    
 0.938
guaB
IMP dehydrogenase/GMP reductase, GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.938
Msm_1734
Predicted thymidylate synthase, ThyA; COG0207.
 
 
 0.936
Msm_1617
Orotidine-5'-phosphate decarboxylase, PyrF; COG0284; Belongs to the OMP decarboxylase family.
    
 0.930
purA
Adenylosuccinate synthetase, PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.927
Msm_0398
Uracil phosphoribosyltransferase, Upp; COG0035.
    
 0.919
Your Current Organism:
Methanobrevibacter smithii
NCBI taxonomy Id: 420247
Other names: M. smithii ATCC 35061, Methanobrevibacter smithii ATCC 35061, Methanobrevibacter smithii DSM 861, Methanobrevibacter smithii PS, Methanobrevibacter smithii str. ATCC 35061, Methanobrevibacter smithii strain ATCC 35061
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