node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mpe_A0707 | guaA | Mpe_A0707 | Mpe_A1622 | Bifunctional regulator/uracil phosphoribosyltransferase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.482 |
Mpe_A0707 | guaB | Mpe_A0707 | Mpe_A1620 | Bifunctional regulator/uracil phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.416 |
Mpe_A0707 | pyrF | Mpe_A0707 | Mpe_A3625 | Bifunctional regulator/uracil phosphoribosyltransferase. | Putative orotidine 5'-phosphate decarboxylase protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.988 |
Mpe_A0707 | pyrH | Mpe_A0707 | Mpe_A1977 | Bifunctional regulator/uracil phosphoribosyltransferase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.940 |
Mpe_A0707 | surE | Mpe_A0707 | Mpe_A1252 | Bifunctional regulator/uracil phosphoribosyltransferase. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
Mpe_A3624 | adk | Mpe_A3624 | Mpe_A2488 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.948 |
Mpe_A3624 | guaA | Mpe_A3624 | Mpe_A1622 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.807 |
Mpe_A3624 | guaB | Mpe_A3624 | Mpe_A1620 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.851 |
Mpe_A3624 | purH | Mpe_A3624 | Mpe_A0485 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.994 |
Mpe_A3624 | pyrF | Mpe_A3624 | Mpe_A3625 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Putative orotidine 5'-phosphate decarboxylase protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.873 |
Mpe_A3624 | pyrH | Mpe_A3624 | Mpe_A1977 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.501 |
Mpe_A3624 | surE | Mpe_A3624 | Mpe_A1252 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.929 |
adk | Mpe_A3624 | Mpe_A2488 | Mpe_A3624 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.948 |
adk | guaA | Mpe_A2488 | Mpe_A1622 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.577 |
adk | guaB | Mpe_A2488 | Mpe_A1620 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.448 |
adk | pyrH | Mpe_A2488 | Mpe_A1977 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.587 |
adk | surE | Mpe_A2488 | Mpe_A1252 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
dut | pyrH | Mpe_A2570 | Mpe_A1977 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.427 |
dut | surE | Mpe_A2570 | Mpe_A1252 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.923 |
guaA | Mpe_A0707 | Mpe_A1622 | Mpe_A0707 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Bifunctional regulator/uracil phosphoribosyltransferase. | 0.482 |