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trpF trpF trpD trpD trpC trpC trpB1 trpB1 trpA trpA trpG trpG trpE trpE pheA pheA hisI hisI hisE hisE purL purL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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trpFTrpF; N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)    
Predicted Functional Partners:
trpD
TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 0.999
trpC
TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpB1
TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.999
trpA
TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.997
trpG
TrpG; Anthranilate synthase component II.
  
 0.996
trpE
TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
 
  
 0.989
pheA
PheA; Predicted bifunctional chorismate mutase/ prephenate dehydratase.
 
  
 0.854
hisI
HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.732
hisE
HisE; phosphoribosyl-ATP pyrophosphatase.
  
  
 0.732
purL
PurL; Predicted phosphoribosylformylglycinamidine synthase.
     
 0.635
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
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