node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BVU_3116 | hisA | BVU_3116 | BVU_3852 | Putative histidinol-phosphate aminotransferase. | Imidazole-4-carboxamide isomerase. | 0.728 |
BVU_3116 | hisB | BVU_3116 | BVU_2364 | Putative histidinol-phosphate aminotransferase. | Histidine biosynthesis bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.964 |
BVU_3116 | hisD | BVU_3116 | BVU_2362 | Putative histidinol-phosphate aminotransferase. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.794 |
BVU_3116 | hisF | BVU_3116 | BVU_3853 | Putative histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.765 |
BVU_3116 | hisG | BVU_3116 | BVU_2361 | Putative histidinol-phosphate aminotransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.750 |
BVU_3116 | hisH | BVU_3116 | BVU_3851 | Putative histidinol-phosphate aminotransferase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.787 |
BVU_3116 | hisI | BVU_3116 | BVU_3854 | Putative histidinol-phosphate aminotransferase. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.962 |
guaA | hisA | BVU_3587 | BVU_3852 | Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Imidazole-4-carboxamide isomerase. | 0.690 |
guaA | hisB | BVU_3587 | BVU_2364 | Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | Histidine biosynthesis bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.525 |
guaA | hisI | BVU_3587 | BVU_3854 | Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.459 |
hisA | BVU_3116 | BVU_3852 | BVU_3116 | Imidazole-4-carboxamide isomerase. | Putative histidinol-phosphate aminotransferase. | 0.728 |
hisA | guaA | BVU_3852 | BVU_3587 | Imidazole-4-carboxamide isomerase. | Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.690 |
hisA | hisB | BVU_3852 | BVU_2364 | Imidazole-4-carboxamide isomerase. | Histidine biosynthesis bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.992 |
hisA | hisC | BVU_3852 | BVU_2363 | Imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.869 |
hisA | hisD | BVU_3852 | BVU_2362 | Imidazole-4-carboxamide isomerase. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.980 |
hisA | hisF | BVU_3852 | BVU_3853 | Imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | BVU_3852 | BVU_2361 | Imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.978 |
hisA | hisH | BVU_3852 | BVU_3851 | Imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BVU_3852 | BVU_3854 | Imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | purU | BVU_3852 | BVU_3850 | Imidazole-4-carboxamide isomerase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.808 |