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pdhB pdhB pdhD pdhD pdhC pdhC pdhA pdhA prsA prsA merA merA pfl pfl gcvH gcvH ldh ldh pyk pyk tktA tktA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pdhBPyruvate dehydrogenase E1 component, beta subunit. (327 aa)    
Predicted Functional Partners:
pdhD
Dihydrolipoamide dehydrogenase.
 
 0.999
pdhC
Dihydrolipoamide acetyltransferase.
 
 0.999
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.999
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.996
merA
Mercuric reductase; This protein contains a single copy of the Heavy-Metal-Associated (HMA) domain.
  
 0.989
pfl
Pyruvate formate lyase.
   
 
 0.935
gcvH
Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 
 0.932
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.930
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.926
tktA
Transketolase requires thiamine pyrophosphate as a cofactor; Belongs to the transketolase family.
  
 
 0.858
Your Current Organism:
Acholeplasma laidlawii
NCBI taxonomy Id: 441768
Other names: A. laidlawii PG-8A, Acholeplasma laidlawii PG-8A, Acholeplasma laidlawii str. PG-8A, Acholeplasma laidlawii strain PG-8A
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