node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLA_0800 | hisA | BLA_0800 | BLA_0798 | Conserved hypothetical protein. | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.725 |
BLA_0800 | hisB | BLA_0800 | BLA_0801 | Conserved hypothetical protein. | COG0131: Imidazoleglycerol-phosphate dehydratase. | 0.853 |
BLA_0800 | hisC | BLA_0800 | BLA_0802 | Conserved hypothetical protein. | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.775 |
BLA_0800 | hisD | BLA_0800 | BLA_0803 | Conserved hypothetical protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.775 |
BLA_0800 | hisH | BLA_0800 | BLA_0799 | Conserved hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.798 |
hisA | BLA_0800 | BLA_0798 | BLA_0800 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Conserved hypothetical protein. | 0.725 |
hisA | hisB | BLA_0798 | BLA_0801 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | COG0131: Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | BLA_0798 | BLA_0802 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.988 |
hisA | hisD | BLA_0798 | BLA_0803 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisE | BLA_0798 | BLA_1314 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | COG0140: Phosphoribosyl-ATP pyrophosphohydrolase. | 0.968 |
hisA | hisF | BLA_0798 | BLA_1304 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | BLA_0798 | BLA_1315 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.979 |
hisA | hisH | BLA_0798 | BLA_0799 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BLA_0798 | BLA_1305 | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | BLA_0800 | BLA_0801 | BLA_0800 | COG0131: Imidazoleglycerol-phosphate dehydratase. | Conserved hypothetical protein. | 0.853 |
hisB | hisA | BLA_0801 | BLA_0798 | COG0131: Imidazoleglycerol-phosphate dehydratase. | Bifunctional HisA/TrpF protein; COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.998 |
hisB | hisC | BLA_0801 | BLA_0802 | COG0131: Imidazoleglycerol-phosphate dehydratase. | COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BLA_0801 | BLA_0803 | COG0131: Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | BLA_0801 | BLA_1314 | COG0131: Imidazoleglycerol-phosphate dehydratase. | COG0140: Phosphoribosyl-ATP pyrophosphohydrolase. | 0.968 |
hisB | hisF | BLA_0801 | BLA_1304 | COG0131: Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |