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rtcA rtcA Tneu_1726 Tneu_1726 tmcA tmcA Tneu_0851 Tneu_0851 nep1 nep1 rps12 rps12 rps6e rps6e rps3ae rps3ae rps4 rps4 rps24e rps24e rps11 rps11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rtcARNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (347 aa)    
Predicted Functional Partners:
Tneu_1726
PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; KEGG: pis:Pisl_0402 pre-mRNA processing ribonucleoprotein, binding region.
 
 
 0.996
tmcA
Protein of unknown function DUF699 ATPase putative; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
   
 
 0.988
Tneu_0851
PFAM: KH type 1 domain protein; KEGG: pis:Pisl_0772 hypothetical protein.
   
 
 0.988
nep1
Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
   
 
 0.987
rps12
Ribosomal protein S23 (S12); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.
    
  0.986
rps6e
PFAM: Ribosomal protein S6e; KEGG: pai:PAE1505 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
    
  0.985
rps3ae
PFAM: ribosomal protein S3Ae; KEGG: pis:Pisl_0771 30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.
  
 
  0.982
rps4
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 0.980
rps24e
PFAM: Ribosomal protein S24e; KEGG: pis:Pisl_1895 transcriptional regulator, fis family; Belongs to the eukaryotic ribosomal protein eS24 family.
  
 
  0.977
rps11
Ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.
    
  0.976
Your Current Organism:
Pyrobaculum neutrophilum
NCBI taxonomy Id: 444157
Other names: P. neutrophilum V24Sta, Pyrobaculum neutrophilum JCM 9278, Pyrobaculum neutrophilum V24Sta, Pyrobaculum neutrophilum str. V24Sta, Pyrobaculum neutrophilum strain V24Sta, Thermoproteus neutrophilus V24Sta
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