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thiM thiM thiE thiE thiD thiD ABZ97091.1 ABZ97091.1 ABZ98791.1 ABZ98791.1 ABZ98790.1 ABZ98790.1 ABZ98788.1 ABZ98788.1 mapB mapB ABZ98787.1 ABZ98787.1 thiC thiC ABZ97907.1 ABZ97907.1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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thiMHydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiD
Phosphomethylpyrimidine kinase (HMP-phosphate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.992
ABZ97091.1
Putative transcriptional activator, TenA family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator.
 
 
 0.985
ABZ98791.1
Two-component response regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator.
       0.821
ABZ98790.1
Hypothetical protein; Doubtful CDS.
       0.817
ABZ98788.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.692
mapB
Methionine aminopeptidase (MAP; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
       0.692
ABZ98787.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.675
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.655
ABZ97907.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
  
 0.591
Your Current Organism:
Leptospira biflexa
NCBI taxonomy Id: 456481
Other names: L. biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc str. ATCC 23582, Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc strain Patoc 1
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